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Teoret. i eksperim. khimiya. 2004. Vol.40 No. 3. p. 133-139

Influence of the Nature and the Structure of Adsorbents
on Interaction with Ibuprofen

 

V. M. Gunko, S. V. Mikhalovsky*, M. Melillo*,
E. F. Voronin, L. V. Nosach, E. M. Pakhlov


Institute of Surface Chemistry, National Academy of Sciences of Ukraine
17 Vul. Generala Naumova, 03164 Kyiv, Ukraine. E-mail: vlad-gun@ln.ua

* University of Brighton
Lewes Road, Brighton, BN2 4GJ UK


Interaction of ibuprofen (2-(4-isobutylphenyl)propionic acid) with a surface of carbon and oxide adsorbents was studied. An essential role of broad pores was shown for adsorption of ibuprofen on car- bon adsorbents in the presence of protein (BSA) molecules. Ibuprofen at low concentrations adsorbs on the surfaces of hydrophilic and hydrophobic adsorbents in the form of monomers, but with increasing concentration the contribution of adsorbed dimers increases.


Key words ibuprofen adsorption, BSA, activated carbons, high-disperse silica.