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10


Teoret. i eksperim. khimiya. 2004. Vol.40 No. 4. p. 250-255

SPR Study of Blocking Activity of Soybean Trypsin Inhibitor
by Macrocyclic Nickel Complex Immobilized on the Surface of Gold

 

B. A. Snopok, P. N. Boltovets, L. V. Tsymbal*, Ya. D. Lampeka*


V. E. Loshkarev Institute of Semiconductor Physics, National Academy of Sciences of Ukraine
45 Prosp. Nauky, 03028 Kyiv, Ukraine. E-mail: snopok@isp.kiev.ua

* L. V. Pysarzhevsky Institute of Physical Chemistry, National Academy of Sciences of Ukraine
31 Prosp. Nauky, 03028 Kyiv, Ukraine. E-mail: lampeka@iphch.kiev.ua


The method of modification of the surface of metallic gold based on the self-organization of macrocyclic nickel(II) complex bearing thiol substituent is proposed. The effect of inhibition of biological activity of by immobilized complex is estimated. It is shown that such an approach could be used for construction of sen- sitive sensor elements able to detect both small molecules (thiocyanate ions) and albumen substrates.


Key words nickel, macrocyclic complex, thiols, albumens, monolayer.