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5


Teoret. i eksperim. khimiya. 2006. Vol.42 No. 2. p. 96-101

Simple Analytical Model of Biosensor Competition Analysis
for Detection of Low Molecular Weight Analytes

 

B. A. Snopok, P. N. Boltovets, F. J. Rowell*


V. E. Lashkarev Institute of Semiconductor Physics, National Academy of Sciences of Ukraine
Prosp. Nauky 41, 03028 Kyiv, Ukraine. E-mail: snopok@isp.kiev.ua

* School of Health, Natural and Social Sciences, University of Sunderland, Fleming Building, Wharncliffe Street,
Sunderland, SR1 3SD, UK. E-mail: Frederick.Rowell@sunderland.ac.uk


A steady-state model of competition inhibition analysis and its application for determination of sulfamethoxazole in aqueous solutions (0,01-100 μg/mL) using surface plasmon resonanse were considered. The analytical expression (logistic curve), connecting the steady-state response of the bio- sensor with the concentration of the low-molecular weight analyte, its immobilized analogue and biologi- cal receptor, was obtained.


Key word competition analysis, logistic curve, biosensors, surface plasmon resonance, sulfamethoxazole.